Literature has also explored the concept of chloroform, often using it as a metaphor for the loss of control or the blurring of reality. Edgar Allan Poe's short story "The Unparalleled Adventure of One Hans Pfaall" (1835) features a character who uses chloroform to ascend a balloon, highlighting the substance's intoxicating properties.

Music has also referenced chloroform, often using it as a metaphor for intoxication, pleasure, or disorientation. The rock band Depeche Mode released a song titled "Chloroform" (1993), which explores themes of desire, control, and disconnection.

The 1970s and 1980s saw a surge in horror movies featuring chloroform, often in "chase" or "kidnapping" scenes. Films like "Halloween" (1978), "The Burning" (1981), and "Sleepaway Camp" (1983) showcased chloroform as a tool for incapacitating victims. These scenes typically involved a character being dragged away, gagged, and chloroformed, heightening the sense of terror and vulnerability.